The 82nd Annual Meeting of the American Association of Physical Anthropologists (2013)


FTO (rs9939609) and INSIG2 (rs7566605) allele distributions in human populations

MICAELA GNES1, LAURA ANZIVINO1, ALBERTO GONZÁLEZ DE LA VEGA2, FLAVIO DE ANGELIS1, OLGA RICKARDS1, MARIA ORERA CLEMENTE2 and CRISTINA MARTÍNEZ-LABARGA1.

1Department of Biology, University of Rome “Tor Vergata”, Italy, 2Laboratory of Genetics, CGC Genetics-Circagen, Madrid, Spain

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It is known the influence of the genetic background in obesity. Double homozygotes AA at FTO gene (rs9939609) and CC at INSIG2 gene (rs7566605) (Chu et al., 2008) have a higher probability to develop morbid obesity than general population. Given their clinical significance, it is of interest to know the distribution of these genetic variants associated with obesity in populations from different continents.

A total of 533 unrelated individuals, from Africa, Asia, America and Europe were typed for rs7566605 (INSIG2) and rs9939609 (FTO) using RT-PCR. The study was approved by the Ethics Committee of the University of Rome “Tor Vergata”.

Double homozygotes individuals AA/CC were found only in the Amhara of Ethiopia, the Libyan Tuaregs, and in the African-Ecuadorian population of Rio Cayapas. The results obtained confirm that the obesity associated genes present a degree of differentiation among populations of distinct continents. They also highlight the usefulness of this kind of research in identifying individuals at higher risk for the development of obesity in view of the current change of lifestyles. A general approach for an integrated analysis of human nutrition, within an anthropological and evolutionary perspective will be unavoidable in order to ravel the complexity of human eating behavior and nutritional disorders.

CGC Genetics-Circagen and MIUR (Ministry of Education, University and Research)

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