The 82nd Annual Meeting of the American Association of Physical Anthropologists (2013)


Trade-offs between reproduction, aging and lifespan: biomarkers, confounders and genetic factors

GRAZYNA JASIENSKA.

Evolutionary Ecology of Health, Jagiellonian University

Friday 3:00-3:15, Ballroom B Add to calendar

Factors related to fertility play crucial, but often unappreciated, role in influencing health, aging and lifespan of modern women. Pregnancy, lactation and childcare are energetically expensive, especially in women with high lifetime reproductive effort and particularly those who are in poor nutritional status. Allocation of resources to support reproduction may cause their insufficient supply to other metabolic functions, resulting in compromised physiology, increased risks of diseases and, consequently, a reduced lifespan. Variation in health, aging and longevity among women may, therefore, be partially explained by differences in their lifetime reproductive effort.

I present an overview of a conceptual and methodological approach that could be used when studying tradeoffs between aging and reproduction. It is important to identify biomarkers of health and aging processes, account for polymorphism in genes having antagonistic pleiotropic effects and provide detailed description of confounding factors. Biomarkers of aging should include quantitative indices of inflammation, cognitive decline, and of muscle strength and symptoms of metabolic syndrome. Information about genotypic identity of participants (with respect to APOE, PPAR-gamma, and IL-10 loci) will allow controlling for pleiotropic relationships between reproductive effort and health status of women. Factors that may alleviate costs of reproduction (e.g. social status, nutritional status, help provided by neighbors and relatives) magnify physiological variation among subjects and should be explicitly controlled in statistical models. Preliminary results of the FEM-AGING study conducted in rural Poland that utilizes this methodological approach will be presented.

This study was supported by Salus Publica Foundation, Yale University Program in Reproductive Ecology, the National Science Centre (grant no. N N404 273440), and the Ministry of Science and Higher Education (grant Ideas Plus no. IdP2011000161).

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