The 84th Annual Meeting of the American Association of Physical Anthropologists (2015)


High altitude adaptation and adaptive introgression in humans

RASMUS NIELSEN.

Departments of Integrative Biology and Statistics, UC Berkeley

March 26, 2015 , Gateway Ballroom 2 Add to calendar

I will discuss recent progress in my group on understanding the genetic basis of altitude adaptation in Tibetans and other humans. In Tibetans we (and other groups) have shown that important altitude adaptions relating to hemoglobin production are caused by mutaitons in the EPAS1 and EGLN1 gene. Recently we have also shown that the adaptive EPAS1 haplotype was transferred into humans by introgression from Denisovans. I will discuss recent progress on understanding the process of adaptive introgression in humans adn its role in altitude adaptation.