The 85th Annual Meeting of the American Association of Physical Anthropologists (2016)

Session 13. Ancient alleles in modern populations: Ancient structure, introgression and variation-maintaining adaptive forces. Invited Podium Symposium. Chair: Omer Gokcumen Co-organizers: Omer Gokcumen, University at Buffalo; Aaron Sams, Cornell University

April 14, 2016 , Imperial Ballroom B Add to calendar

It was an amazing decade for anthropological genetics. Improvements in sequencing technologies have, on the one hand, provided thousands of whole modern human genomes readily available for analysis, and on the other hand, allowed sequencing of whole ancient genomes, a feat that revolutionized the way in which we study human evolution. One of the most fascinating areas of research that has developed from these new resources is the observation that modern humans share derived alleles with archaic populations, such as Neandertals and Denisovans, and some of these alleles remain variable in human populations. This observation is concordant with three scenarios: (i) recent introgression events from the archaic humans into modern human populations; (ii) ancient structure in the ancestral human population(s); and (iii) recurrent mutations at orthologous loci. It is now clear that all these scenarios have considerable influence on shaping the landscape of modern human genomic variation. In addition, some of these ancient variants have been maintained through adaptive forces, especially involving variation-maintaining adaptive forces (i.e., different ramifications of balancing selection). These adaptations relate to evolutionarily important functional categories, such as immunity, metabolism, growth, and climatic adaptation. This symposium will bring together paleoanthropologists, genetic anthropologists and population geneticists who are leaders in the field to lay out state-of-the-art methodological and theoretical developments involving genetic variation that has been maintained for hundreds of thousands of years in the human lineage. We hope that this symposium will lead to novel discussion regarding recent human evolution, the ancient migrations that shaped contemporary genetic structure in humans, and the adaptive impact of ancient human variation.

1:00 Add to calendar The high-quality genomes of a Neandertal and a Denisovan. Kay Prüfer.
1:15 Add to calendar A discriminative model for inferring genome-wide maps of Neandertal and Denisovan ancestry. Sriram Sankararaman, Swapan Mallick, Nick Patterson, David Reich.
1:30 Add to calendar The genomic footprints of Stone-Age Europeans. Mattias Jakobsson.
1:45 Add to calendar Ancient introgression in Africa and the evolutionary genetics of hybrid fitness effects. Joseph Lachance.
2:00 Add to calendar A novel approach for detecting adaptive introgression in modern humans. Emilia Huerta-Sanchez, Fernando Racimo.
2:15 Add to calendar A novel, probabilistically interpretable framework for localizing genomic elements underlying adaptive evolution. Sohini Ramachandran, Lauren A. Sugden.
2:30 Add to calendar Adaptive maintenance of ancient alleles: likelihood approaches for detecting balancing selection. Michael DeGiorgio, Kirk E. Lohmueller, Rasmus Nielsen.
2:45 Add to calendar Balancing selection and adaptive introgression as sources of advantageous genetic diversity in populations. Aida M. Andrés, Michael Dannemann, Joao Teixeira, Janet Kelso.
3:00 Add to calendar Effects of adaptive Neandertal introgression at the OAS locus on the modern human innate immune response. Aaron J. Sams, Johann Nedelec, Anne Dumain, Vania Yotova, Philipp W. Messer, Luis B. Barreiro.
3:15 Add to calendar Ancient alleles and complex structural variation of pathogen receptors at the glycophorin locus. Ellen M. Leffler, Gavin Band, Kirk A. Rockett, Quang Si Le, Dominic P. Kwiatkowski, Chris C.A. Spencer.
3:30 Add to calendar Ancient genetic diversity and an evolutionary medicine perspective on Neandertal extinction. Alexis P. Sullivan, George Perry.
3:45 Add to calendar Millennial-scale population dynamics and the anthropology of introgression. John Hawks.
4:00 Discussion: Omer Gokcumen
4:15 Break