The 88th Annual Meeting of the American Association of Physical Anthropologists (2019)


Heritability of the Body Composition and Blood Pressure association in ethnically distinct indigenous populations

SUDIPTA GHOSH1, TASBULAT DOSAEV2, JAI PRAKASH3 and GREGORY LIVSHITS3.

1Anthrpology, North-Eastern Hill University, 2Anatomy, Asfendiyarov Kazakh National Medical University, 3Anatomy and Anthropology, Tel-Aviv University

March 28, 2019 6:00, CC Room 26 C Add to calendar

The present paper is an attempt to understand ethnic variations in the association of blood pressure with body composition in two geographically and ethnically diverse adult populations, i.e. Santhal, an indigenous group from India and Chuvash, an indigenous population from Russia. In addition, the paper attempts to identify genetic and/or environmental factors that contribute to this association. Pedigree samples were collected from these two ethnically different populations. The multiple and multivariate regression frameworks were used in the paper. Contribution of genetic and shared familial environmental factors to variation and co-variation of the studied parameters were examined by quantitative genetic analysis using the Mendelian Analysis Package.

In somatotype, both the environmentally diverse populations are found to be predominantly mesomorphic irrespective of their sex. According to the multiple multivariate regression analysis results, age but not sex is an important confounder for blood pressure variations in both the samples. In addition, variance decomposition analysis indicates that fat mass, mesomorphic component and fat free mass have considerable influence on the variation of blood pressure. Heritability estimates are significant for all the blood pressure and body composition traits in both the populations ranging between 0.125±0.058 (Chuvash, ectomorphy) and 0.625±0.084 (Santhal, FFMI), being however as a rule ≥0.250±0.086.Hence, additive genetic component contribute to a substantial proportion of blood pressure and body composition variance. Resemblances in genetic and other covariates of blood pressure in these two populations perhaps suggest a basic pattern in epigenetic interactions that are possibly shared by the entire human species.

Ministry of tribal affairs, Government of India & Israel Science Foundation.