The 89th Annual Meeting of the American Association of Physical Anthropologists (2020)


Serum inflammation in Guamanian Amyotrophic Lateral Sclerosis and Parkinsonism Dementia:  A nested case-control pilot study

RISANA N. CHOWDHURY1, ERIN CULVER2, UMER WATTOO2, FARRAH MARGOLIN3, THU NGUYEN2, RALPH M. GARRUTO1,2, KATHERINE WANDER1 and KOJI LUM1,2.

1Anthropology, SUNY-Binghamton, 2Biological Sciences, SUNY-Binghamton, 3Integrative Neurosciences, SUNY-Binghamton

April 16, 2020 , Platinum Ballroom Add to calendar

In 1945 Guam, the leading cause of premature death in the local population was a neurodegenerative disease that had symptoms of either Parkinsonism-dementia(PD) or Amyotrophic Lateral Sclerosis(ALS). Guamanians developed these symptoms-a combination of tremors and dementia or progressive motor function loss-at 40-50 times worldwide average. Many ALS patients lived unusually long(20+ years) without respirators or medical treatment.

The purpose of this study was to observe change in serum inflammation of Guamanian ALS and PD patients before and after disease onset. Among longitudinally sampled participants, incident cases were identified, and pre-diagnosis and post-diagnosis specimens were evaluated(n=21). Two age-, sex-, and region-matched controls for the pre-diagnosis and post-diagnosis time points were also evaluated. Biomarkers associated with duration and/or severity of neurodegenerative disease (specifically: monocyte chemoattractant protein(MCP)-1 and -2, interferon-gamma induced protein(IP)-10, interleukin-8, TARC, eotaxin-1 and RANTES) were evaluated in serum specimens via Quansys immunoassay. These biomarkers have been validated for stability in archived frozen human sera.

MCP-2 is elevated in post vs. pre-ALS-onset specimens(p:0.015), and between post-onset ALS and PD specimens(p:0.007). MCP-2 is marginally significant in post-onset ALS vs. control specimens(p:0.068). RANTES is marginally significant in post vs. pre-ALS-onset specimens(p:0.089) and pre-ALS-onset vs. controls(p:0.076). IP-10 is marginally significant in post vs. pre-PD-onset specimens(p:0.08) and in pre-onset PD patients vs. controls(P:0.09). Findings suggest neurodegenerative diseases have an inflammatory component across diverse environments.

This study was funded by Binghamton University URA and Harpur Edge.